Gentamicin: The Aminoglycoside for Serious Bacterial Infections
What is Gentamicin?
Gentamicin is an aminoglycoside antibiotic used for the treatment of serious bacterial infections, particularly those caused by gram-negative bacteria. It is often used in hospital settings for life-threatening infections like sepsis and pneumonia.
How Gentamicin Works
Gentamicin works by binding to bacterial ribosomes, preventing protein synthesis, which ultimately kills the bacteria.
When to Use Gentamicin
● Sepsis: For serious bloodstream infections.
● Urinary Tract Infections: Treats severe UTIs.
● Pneumonia and Meningitis: Treats life-threatening respiratory and brain infections.
Dosage
● Adult Dose: 3-5 mg/kg/day, administered intravenously or intramuscularly in divided doses. In cases of meningitis, severe infections and extended interval dosing it can be given upto 5 – 7 mg/kg/day.
● Pediatric Dose: 2- 2.5 mg/kg/dose every 8 hours. In cases of endocarditis and meningitis the dose can be increased to 3-6 mg/kg/day and 7.5 mg/kg/day respectively.
Side Effects
● Nephrotoxicity (kidney damage), ototoxicity (hearing damage), and dizziness, edema, hypertension.
Common Brands in India: Garamycin, Gentamicin.
FAQ
Can Gentamicin be used for eye infections?
Yes, it can be used in eye drops to treat bacterial eye infections.
Does Gentamicin cause hearing loss?
Ototoxicity is a possible side effect, especially with high doses or prolonged use.
Can Gentamicin be combined with other antibiotics?
Yes, it is often used in combination therapy for severe infections.
Disclaimer
Gentamicin should be used with caution due to its potential toxicity. HealthPil provides access to infectious disease specialists for safe antibiotic use.