Prednisone: The Steroid for Inflammation and Immune Disorders
What is Prednisone?
Prednisone is a synthetic anti-inflammatory glucocorticosteroid used to treat various conditions, including inflammatory disorders, autoimmune diseases, and allergic reactions. It suppresses the immune system and reduces inflammation, which helps manage conditions like arthritis, asthma, and skin conditions.
How Prednisone Works
Prednisone decreases the inflammation by suppression of migration of neutrophils and decreasing capillary permeability. Its action is similar to that of cortisol from adrenal gland. It decreases inflammation by suppressing the immune system’s activity and inhibits the production of substances that promote inflammation, such as prostaglandins.
When to Use Prednisone
● Autoimmune Disorders: Prednisone is used to treat diseases like rheumatoid arthritis, lupus, and multiple sclerosis.
● Inflammatory Conditions: It is effective for treating conditions like inflammatory bowel disease (IBD), asthma, and eczema.
● Allergic Reactions: Prednisone is used for severe allergic reactions or for managing anaphylaxis in combination with other treatments.
Dosage
● Adult Dose: The typical starting dose is 5 mg to 60 mg per day, depending on the condition being treated.
● Pediatric Dose: Prednisone dosing for children is typically based on body weight, starting at 1 mg/kg/day.
Side Effects
● Common Effects: Weight gain, increased appetite, fluid retention, and high blood sugar.
● Serious Adverse Effects: Long-term use can lead to osteoporosis, immune suppression, and gastric ulcers.
Common brands: Wysolone, Mornipred