Levetiracetam: The Antiepileptic Drug for Seizure Control
What is Levetiracetam?
Levetiracetam is an antiepileptic drug (AED) used to treat various types of seizures, including partial-onset, myoclonic, and tonic-clonic seizures. It works by stabilizing electrical activity in the brain and preventing abnormal brain cell firing.
How Levetiracetam Works
Levetiracetam binds to the SV2A protein in the brain, which is involved in neurotransmitter release. This action reduces the excessive neuronal firing associated with seizures and helps control seizure activity.
When to Use Levetiracetam
● Seizures: Levetiracetam is prescribed for epilepsy and seizure disorders to prevent different types of seizures, including focal seizures and generalized tonic-clonic seizures.
● Adjunct Therapy: It is often used in combination with other antiepileptic medications for better seizure control.
Dosage
● Adult Dose for Seizures: The typical starting dose is 500 mg twice daily, with adjustments based on response and can be increased to 40-60 mg/kg up to maximum of 3000-4500mg. .
● Pediatric Dose: The dose for children is typically 10 mg/kg/day, increasing gradually depending on age and weight.
Side Effects
● Common Effects: Drowsiness, dizziness, irritability, and fatigue.
● Serious Adverse Effects: Mood changes, depression, and suicidal thoughts in some individuals.
Common brands: Levipil.