Ranitidine: The Histamine H2-Receptor Antagonist for Stomach Ulcers and Acid Reflux
What is Ranitidine?
Ranitidine is a histamine H2-receptor antagonist used to treat conditions such as acid reflux, stomach ulcers, and gastritis. It works by decreasing the amount of stomach acid produced, which helps to heal ulcers and prevent damage caused by acid.
How Ranitidine Works
Ranitidine blocks the H2 receptors in the stomach lining, which are responsible for stimulating acid production. By inhibiting these receptors, Ranitidine reduces the amount of gastric acid produced, thereby treating conditions like gastroesophageal reflux disease (GERD) and ulcers.
When to Use Ranitidine
● Gastroesophageal Reflux Disease (GERD): It is used to relieve symptoms of acid reflux and prevent esophageal damage.
● Stomach Ulcers: Ranitidine is used to treat duodenal and gastric ulcers, promoting healing by reducing acid secretion.
● Gastritis: It can help treat gastritis, especially when caused by excessive acid production.
Dosage
● Adult Dose for GERD: Typically, 150 mg twice daily or 300 mg once at bedtime.
● Adult Dose for Ulcers: 150 mg twice daily or 300 mg once daily for up to 8 weeks.
● Pediatric dose: started with 4-8 mg/kg/day in two divided doses. Maximum dose is 300 mg/day
Side Effects
● Common Effects: Headache, dizziness, constipation, and diarrhea.
● Serious Adverse Effects: Liver toxicity, arrhythmias, and severe allergic reactions.
Common brands: Aciloc, Rantac.