Teicoplanin: A Potent Antibiotic for Serious antibiotic resistant Infections like MRSA
Teicoplanin is a glycopeptide antibiotic used to treat serious bacterial infections, particularly those caused by gram-positive bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). It works by inhibiting cell wall synthesis in bacteria, ultimately leading to their death.
Mechanism of Action
Teicoplanin binds to the D-alanyl-D-alanine portion of the bacterial cell wall precursor, preventing cell wall synthesis, which leads to bacterial lysis.
Indications
● MRSA Infections: For infections resistant to other antibiotics.
● Endocarditis: Infections of the heart valves.
● Soft Tissue Infections: Severe skin and tissue infections.
Dosage and Administration
● Adults: Initial dose is 6-12 mg/kg every 12 hours for 3-5 doses, adjusted based on the severity of the infection. Treatment should not exceed 4 months.
● Pediatric Dosage: Adjusted based on weight and condition severity. Initially given 10-16 mg/kg on day 1 and 8 mg/kg once a day on subsequent doses.
Side Effects
● Common: Nausea, fever, rash, and phlebitis (inflammation of veins).
● Serious: Nephrotoxicity (kidney damage) and ototoxicity (hearing damage).
Pregnancy Category: Category C – Use only if necessary during pregnancy.
Common Brands
● Targocid
