Granisetron: The Antiemetic for Chemotherapy-Induced Nausea and Vomiting
What is Granisetron?
Granisetron is a serotonin 5-HT3 receptor antagonist used to prevent and treat chemotherapy-induced nausea and vomiting (CINV). It blocks the receptors in the brain that are responsible for triggering nausea and vomiting during chemotherapy.
How Granisetron Works
Granisetron works by inhibiting the action of serotonin, a chemical that triggers nausea and vomiting after chemotherapy. By blocking the these receptors, it reduces the occurrence of nausea, vomiting, retching.
When to Use Granisetron
● Chemotherapy-Induced Nausea and Vomiting (CINV): Prevents and treats nausea and vomiting caused by chemotherapy.
● Post-Surgical Nausea and Vomiting (PONV): Reduces nausea after surgery.
Dosage
● Adult Dose: 1 mg intravenously before chemotherapy, followed by 1 mg orally once daily for up to 5 days.
● Pediatric Dose: 0.01 mg/kg IV before chemotherapy.
Side Effects
● Headache, constipation, dizziness, and fatigue.
Common Brands in India: Kytril, Granisol.
FAQ
Can Granisetron be used for motion sickness?
No, Granisetron is specifically used for nausea related to chemotherapy and surgery.
Is Granisetron safe for children?
Yes, but the dosage should be carefully adjusted based on the child’s weight.
How soon does Granisetron start working?
Granisetron typically begins to work within an hour of administration.
Disclaimer
Granisetron should be used as prescribed by your doctor. HealthPil provides access to oncologists and anesthesiologists for proper management of chemotherapy side effects.
