Tamoxifen: A Lifesaving Treatment for Estrogen-Receptor-Positive Breast Cancer
Tamoxifen is a selective estrogen receptor modulator (SERM) used to treat hormone receptor-positive breast cancer in both men and women. It blocks the estrogen receptors on cancer cells, preventing estrogen from stimulating tumor growth. It is also prescribed to minimize the recurrence of breast cancer in adult patients when used as an adjuvant therapy for the treatment of breast cancer.
Mechanism of Action
Tamoxifen binds to estrogen receptors on tumor cells, blocking estrogen’s ability to stimulate the cancer cells. This slows or halts the growth of hormone-sensitive tumors.
Indications
● Breast Cancer: For both treatment and prevention in women with hormone receptor-positive breast cancer.
● Fertility Treatment: Occasionally used to stimulate ovulation in women with fertility issues.
Dosage and Administration
● Adults: 20 mg daily, for 5–10 years after initial breast cancer treatment.
● Fertility treatment (off-label use): 20-30 mg daily for 3-6 months only then proceeding to assisted reproductive therapy if not conceived.
Side Effects
● Common: Hot flashes, nausea, fatigue, and mood swings.
● Serious: Increased risk of endometrial cancer, blood clots, and stroke.
Pregnancy Category: Category D – Contraindicated during pregnancy.
Common Brands
● Nolvadex
● Tamodex
● Cytotam