Sevelamer: A Phosphate Binder for Managing Hyperphosphatemia in Chronic Kidney Disease
Sevelamer is a phosphate binder used to lower phosphate levels in patients with chronic kidney disease (CKD). Elevated phosphate levels can lead to complications such as bone disease and cardiovascular events. This article explores Sevelamer’s role in managing CKD, its dosage, side effects, and common brands in India.
What is Sevelamer?
Sevelamer is a polymeric compound which binds to phosphate in the gastrointestinal tract, preventing its absorption. It is used in patients with CKD who are undergoing dialysis to reduce phosphate levels and prevent complications associated with hyperphosphatemia. It does not alter calcium, bicarbonate and aluminum concentrations in the body.
Indications for Sevelamer
● Hyperphosphatemia in Chronic Kidney Disease: Reduces phosphate absorption in the gastrointestinal tract, preventing high phosphate levels in blood.
Dosage and Administration
● For Hyperphosphatemia: Initial dose of 800-1,600 mg three times daily with meals, adjusted based on serum phosphate levels.
● Pediatric dosage: The dose is titrated according to the body surface area
<1.2 m2 : 800 mg TID with meals.
> 1.2 m2 : 1600 mg TID with meals.
Side Effects of Sevelamer
● Common: Gastrointestinal issues, including nausea, vomiting, constipation, and diarrhea.
● Serious: Bowel obstruction, gastrointestinal bleeding, and severe abdominal pain.
● Pregnancy Category: Category C (use when necessary and with caution).
Common Brands in India
● Renagel
● Revlamer
● Sevelamer (Generic)
