Chlorpromazine is a typical antipsychotic medication from the phenothiazine class. It is commonly used to treat psychiatric disorders like bipolar disorder, schizophrenia, and severe behavioral problems. Chlorpromazine acts on the dopamine receptors in the brain by blocking them, which helps to alleviate symptoms of psychosis and stabilize mood.
Common Uses of Chlorpromazine
● Schizophrenia
● Bipolar disorder (manic episodes)
● Severe behavioural problems (particularly in children)
● Nausea and vomiting
● Persistent, severe hiccups
● Tetanus (as adjunct therapy)
● Intractable hiccups
Dosage and Administration
● Schizophrenia: Start with 25 mg orally, three times a day, gradually increasing to a maintenance dose of 300-400 mg per day, divided into 3-4 doses.
● Bipolar Disorder: 25-50 mg orally, three times daily, adjusted as necessary depending on the patient’s response.
● Severe Behavioural Problems: 0.55 mg/kg every 4-6 hours as required, with a maximum of 75 mg per day.
● Nausea and Vomiting: 10-25 mg orally, every 4-6 hours as necessary.
● Hiccups: 25-50 mg orally, 3-4 times a day.
Chlorpromazine is available in various forms, including tablets, injections, and syrup. Dosages are tailored according to the severity of the condition and the patient’s response to treatment.
Possible Side Effects of Chlorpromazine
● Drowsiness and sedation
● Low blood pressure (orthostatic hypotension)
● Movement disorders (e.g., tardive dyskinesia, dystonia)
● Weight gain
● Anticholinergic effects ( dry mouth, constipation, blurred vision)
● Elevated prolactin levels (hyperprolactinemia)
● Neuroleptic malignant syndrome (rare but life-threatening condition)
Contraindications of Chlorpromazine
● Coma or severe central nervous system (CNS) depression
● Bone marrow suppression
● Serious liver or heart conditions
● Allergy to chlorpromazine or other phenothiazines
Special Considerations for Chlorpromazine
● Pregnancy: Classified as FDA Category C, chlorpromazine should be used during pregnancy only if the benefits justify the potential risks, especially in the third trimester due to possible effects on the fetus.
● Liver Health: Careful monitoring is required for patients with liver issues, as chlorpromazine is metabolized by the liver and could cause liver damage or jaundice.
● Kidney Health: Although no significant dose adjustments are needed for kidney function, patients with severe renal impairment should be closely monitored.
Brand Names of Chlorpromazine
● India: Largactil, Chlorprom
● USA: Thorazine
Why Choose HealthPil for Your Treatment?
At HealthPil, our team of psychiatrists is experienced in managing complex psychiatric conditions like schizophrenia and bipolar disorder. If you or a loved one is dealing with these challenges, our experts can guide you on whether chlorpromazine is the right option. Book your consultation with our specialists today!
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a healthcare provider before starting any new medication, including chlorpromazine, and follow their instructions for safe use.
