Vancomycin: The Go-To Antibiotic for Severe Gram-Positive Infections
Vancomycin is an antibiotic primarily used to treat serious infections caused by gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). It is often used in hospital settings for severe infections when other antibiotics may not be effective.
Mechanism of Action
Vancomycin works by inhibiting the bacterial cell wall synthesis, preventing the bacteria from forming the structure needed to survive and grow.
Indications
● MRSA Infections: For treating severe infections that are resistant to other antibiotics.
● Endocarditis: For treating infections of the heart valves.
● Pneumonia: Caused by resistant gram-positive bacteria.
● Soft Tissue Infections: Including abscesses caused by MRSA.
Dosage and Administration
● Adults: For MRSA infections, 15 mg/kg every 12 hours, adjusted based on renal function and infection severity.
● Pediatric Dosage: Adjusted based on weight and infection.
Side Effects
● Common: Redness, rash, and pain at the injection site.
● Serious: Nephrotoxicity (kidney damage), ototoxicity (hearing loss), and hypotension.
Pregnancy Category: Category C – Use during pregnancy only if the benefits outweigh the risks.
Common Brands
● Vancocin