Pentoxifylline: The Medication for Peripheral Artery Disease
What is Pentoxifylline?
Pentoxifylline is a phosphodiesterase inhibitor used to improve blood flow and treat symptoms of peripheral artery disease (PAD). It helps reduce blood viscosity and improves the flexibility of red blood cells, allowing for better circulation and oxygen delivery to tissues.
How Pentoxifylline Works
Pentoxifylline works by increasing the flexibility of red blood cells and reducing blood viscosity, which improves blood flow to tissues affected by poor circulation, such as in PAD.
When to Use Pentoxifylline
● Peripheral Artery Disease (PAD): Pentoxifylline is used to relieve symptoms of claudication (leg pain caused by poor circulation) and improve walking distance in patients with PAD.
● Chronic Venous Insufficiency: It is sometimes used to treat chronic venous ulcers and improve blood flow in the veins.
Dosage
● Adult Dose: Typically, 400 mg three times daily with food.
● Pediatric Dose: Pentoxifylline is not typically used in children but can be used in Kawasaki disease at 20 mg/kg/day in 3 divided doses.
Side Effects
● Common Effects: Nausea, dizziness, headache, and stomach upset.
● Serious Adverse Effects: Bleeding disorders, liver toxicity, and low blood pressure.
Common brands: Trental, Flexital.