Ibuprofen

Ibuprofen: A commonly prescribed Pain Killer Medicine

What is Ibuprofen?

Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) is commonly used to relieve mild to moderate pain, control fever, and inflammation. It is often recommended for conditions such as headaches, muscle aches, back pain, and arthritis. It is also used to close clinically significant patent ductus arteriosus (a congenital heart defect) in premature infants.

How Ibuprofen Works

Ibuprofen works by inhibiting COX enzymes, which are responsible for producing prostaglandins, the chemicals that cause pain, swelling, and fever. Other than its primary mechanism it also helps in decreasing cytokine production, decreasing neutrophil accumulation and other inflammatory markers.

When to Use Ibuprofen

● Pain Relief: For mild to moderate pain, such as headaches, menstrual cramps, or dental pain.
● Fever Reduction: Used for managing fevers due to infections or other causes.
● Inflammation Control: Effective for treating conditions like rheumatoid arthritis, osteoarthritis, and muscle injuries.

Dosage

● Adult Dose: 200-400 mg every 4-6 hours, not exceeding 2400 mg per day.
● Pediatric Dose: 5-10 mg/kg every 6-8 hours, not exceeding 40 mg/kg per day.

Side Effects

● Common Effects: Stomach irritation, dizziness, headache, nausea, and rashes.
● Serious Adverse Effects: Prolonged use can lead to gastric ulcers, gastrointestinal bleeding, renal dysfunction, and high blood pressure. There is an increased risk of heart attack and stroke with long-term or high-dose use.

Common Brands in India: Brufen, Ibugesic.