Ganciclovir: The Antiviral for Cytomegalovirus Infections
What is Ganciclovir?
Ganciclovir is an antiviral medication mostly used to prevent cytomegalovirus (CMV) infections in adult transplant recipient patients who are at risk of contacting the infection. It is also used to treat and prevent eye infections such as CMV retinitis in immunocompromised patients, such as those with HIV/AIDS.
How Ganciclovir Works
Ganciclovir inhibits the replication of the CMV virus by interfering with its DNA synthesis, preventing the virus from multiplying and spreading.
When to Use Ganciclovir
● Cytomegalovirus Infections: Treats active CMV infections, particularly in immunocompromised patients.
● CMV Retinitis: Used in the treatment of CMV retinitis in HIV-positive patients.
Dosage
● Adult Dose: Induction therapy 5 mg/kg every 12 hours intravenously for 14 -21 days and 5 mg/kg/day OD continuously for 7 days a week to as long as needed in the form of maintenance therapy.
● Pediatric Dose: 5 mg/kg every 12 hours for children with CMV infections.
Side Effects
● Fever, diarrhea, neutropenia (low white blood cell count), liver toxicity.
Common Brands in India: Cytovene.
FAQ
Is Ganciclovir effective for all viral infections?
No, it is specific to cytomegalovirus infections and is not effective against other viral infections.
Can Ganciclovir be used during pregnancy?
It is classified as a Category C drug by the FDA, meaning it should be used only if absolutely necessary.
How is Ganciclovir administered?
It is typically administered intravenously in a hospital setting, but oral forms are also available.
Disclaimer
Ganciclovir should be used only under the supervision of a healthcare provider. HealthPil connects you with infectious disease specialists for managing viral infections.
